1560 - Iroquoian tribes south of the Great Lakes, at war with each other and surrounded by more numerous Algonquian enemies, are on the verge of extinction.
Already at war with other Iroquoian tribes, the Wyandots begin to move west.1541 - May 8; Soto reaches the Mississippi River, having marched overland from the Floridas.
The brutal behavior of the Spanish has a devastating effect on the tribes of the southeast; perhaps coincidently, Mississippian culture enters a rapid decline.c.
The town's French population still numbers just 65, with only 20 adult males. Hundreds of Hurons are put to death, along with Father Jean de Brebeuf and Father Gabriel Lalement.
March 16; 1,200 well-armed Iroquois launch coordinated attacks into Ouendake, wiping out the mission towns of St. Ossossane is abandoned as the Huron Confederacy disintegrates. In December, the Petun lose their principal town to the Iroquois.
A third Wyandot group, the Attiwandaronk, called the Neutrals because of their stance in Wyandot-Iroquois conflicts, occupies the country west of Niagara.1609 - July 30; Champlain accompanies a mixed war party of Hurons and Algonkins to the lake which now bears his name, where with his aid they inflict a major defeat on the Iroquois.
The Iroquois discover firearms.1629 - August 9; after a relief expedition sent by Richelieu from France is captured by privateers, Champlain is forced to surrender Quebec to the English.Respected by surrounding Algonquian tribes, the Wyandots are now regarded by the Six Nations as their viceroys in Ohio.Their influence greatly exceeds their numbers.1738 - The Wyandot chief Orontony, called Nicholas, has become estranged from the Ottawa and the French.The majority of the Munsee move north from Pennsylvania to settle in Canada.A few rejoin the main group of Delaware.1754 - Delaware in western Pennsylvania join the Shawnee in raiding the settlements, more out of hatred of the English than love of the French.From this point, the Iroquois regard the Delaware as a subserviant people.