Her mother Jeanette D'Souza was a managing director of the Pharma Multinational corporation.
She left her job in 2004 to help Genelia with her career.
She has appeared in South Indian cinema and Bollywood films.
In 2008, she gave critically acclaimed performances in Santosh Subramaniam, a Tamil remake of Bommarillu, and the Bollywood movie Jaane Tu... Having acted in several commercially successful movies in Telugu and Tamil, Genelia has established herself as one of the leading actresses of the South Indian film industry.
In addition to mainstream acting, Genelia has hosted the television show Big Switch, and is the brand ambassador of Fanta, Virgin Mobile India, Fastrack, LG Mobiles, Garnier Light, Margo, and Perk in India.
The movie, though noted for its vulgar sexual content, was a box-office success, In 2004, Genelia appeared in her second Bollywood movie, Masti.
The comedy focuses on three close friends who reunite after three years, but are now married and are being harassed by their wives.
She also holds a Limca world record of delivering four different super hit films in four different languages, Ready (Telugu), Satya in Love (Kannada), Santosh Subramaniam (Tamil), and Jaane Tu...
Ya Jaane Na (Hindi) in a span of one calendar year.
She signed three movies simultaneously in three different languages, Tujhe Meri Kasam (Hindi), Boys (Tamil), and Satyam (Telugu).
The same year, she made her Tamil debut as the teenage girl Harini in Boys, a story about five teenagers having stereotypical teen-boy fantasies.
Her father Neil D'Souza, is a senior official with Tata Consultancy Services (TCS).